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This decline correlates with reduced tissue regeneration capacity.[2][3] Structurally, GHK-Cu features a Cu(II) ion coordinated in a distorted square-planar pyramid by four nitrogen atoms: the amino-N of glycine, the amide-N of the Gly-His peptide bond, the imidazole-N of histidine, and an oxygen from water or a carboxyl group

Among the most frequently reported adverse effects are minor and self-limiting such as local injection site erythema, transient hormonal shifts, and receptor desensitization with prolonged or high-frequency use

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